pac1r antibody Search Results


pac1r antibody  (ABclonal Biotechnology)
90
ABclonal Biotechnology pac1r antibody
OM-LV20 inhibited phosphorylation of MAPK signaling pathway and increased levels of TPH1 and <t>PAC1R</t> in CTX-TNA2 cells under H 2 O 2 stimulation. A , representative Western blots of MAPK, TPH1, and PAC1R protein levels in CTX-TNA2 cells. B , OM-LV20 significantly promoted mRNA level of PAC1R. C – F , histogram of PAC1R, TPH1, p-JNK, and p-p38 protein expression, respectively. Data are means ± SEM. n = 3, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.
Pac1r Antibody, supplied by ABclonal Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pac1r antibody/product/ABclonal Biotechnology
Average 90 stars, based on 1 article reviews
pac1r antibody - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


OM-LV20 inhibited phosphorylation of MAPK signaling pathway and increased levels of TPH1 and PAC1R in CTX-TNA2 cells under H 2 O 2 stimulation. A , representative Western blots of MAPK, TPH1, and PAC1R protein levels in CTX-TNA2 cells. B , OM-LV20 significantly promoted mRNA level of PAC1R. C – F , histogram of PAC1R, TPH1, p-JNK, and p-p38 protein expression, respectively. Data are means ± SEM. n = 3, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.

Journal: The Journal of Biological Chemistry

Article Title: Peptide OM-LV20 protects astrocytes against oxidative stress via the ‘PAC1R/JNK/TPH1’ axis

doi: 10.1016/j.jbc.2022.102429

Figure Lengend Snippet: OM-LV20 inhibited phosphorylation of MAPK signaling pathway and increased levels of TPH1 and PAC1R in CTX-TNA2 cells under H 2 O 2 stimulation. A , representative Western blots of MAPK, TPH1, and PAC1R protein levels in CTX-TNA2 cells. B , OM-LV20 significantly promoted mRNA level of PAC1R. C – F , histogram of PAC1R, TPH1, p-JNK, and p-p38 protein expression, respectively. Data are means ± SEM. n = 3, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001.

Article Snippet: Primary antibodies included the following: GAPDH (1:3000; Proteintech); p-JNK, JNK, p-p38, and p38 (1:2000; Cell Signaling); TPH1 (1:500; Abcam); and PAC1R (1:500; ABclonal).

Techniques: Phospho-proteomics, Western Blot, Expressing

OM-LV20 regulated TPH1 by binding to PAC1R in CTX-TNA2 cells. A , yellow represents PAC1R conformation, and blue represents OM-LV20 conformation. PAC1R and OM-LV20 showed good shape complementarity. B , yellow is residue of OM-LV20, and blue is PAC1R protein residue. LEU1 formed hydrogen bonds with receptor proteins SER23 and ASN60; LYS4 formed hydrogen bonds with receptor protein ILE19; ALA9 formed hydrogen bonds with TYR118. C , yellow is hydrophobic residue of OM-LV20, and blue is hydrophobic residue of PAC1R protein. They showed hydrophobic accumulation and Van der Waals interactions. D , application of PACAP6-38 partly weakened increase in TPH1 by OM-LV20. E , histogram of TPH1 protein expression. Data are means ± SEM. n = 7, ∗ p < 0.05, ∗∗ p < 0.01.

Journal: The Journal of Biological Chemistry

Article Title: Peptide OM-LV20 protects astrocytes against oxidative stress via the ‘PAC1R/JNK/TPH1’ axis

doi: 10.1016/j.jbc.2022.102429

Figure Lengend Snippet: OM-LV20 regulated TPH1 by binding to PAC1R in CTX-TNA2 cells. A , yellow represents PAC1R conformation, and blue represents OM-LV20 conformation. PAC1R and OM-LV20 showed good shape complementarity. B , yellow is residue of OM-LV20, and blue is PAC1R protein residue. LEU1 formed hydrogen bonds with receptor proteins SER23 and ASN60; LYS4 formed hydrogen bonds with receptor protein ILE19; ALA9 formed hydrogen bonds with TYR118. C , yellow is hydrophobic residue of OM-LV20, and blue is hydrophobic residue of PAC1R protein. They showed hydrophobic accumulation and Van der Waals interactions. D , application of PACAP6-38 partly weakened increase in TPH1 by OM-LV20. E , histogram of TPH1 protein expression. Data are means ± SEM. n = 7, ∗ p < 0.05, ∗∗ p < 0.01.

Article Snippet: Primary antibodies included the following: GAPDH (1:3000; Proteintech); p-JNK, JNK, p-p38, and p38 (1:2000; Cell Signaling); TPH1 (1:500; Abcam); and PAC1R (1:500; ABclonal).

Techniques: Binding Assay, Residue, Expressing

Neuroprotective mechanism of OM-LV20 in astrocytes. Peptide OM-LV20 exerts protective effects on astrocytes via the ‘PAC1R/JNK/TPH1’ axis to resist oxidative stress.

Journal: The Journal of Biological Chemistry

Article Title: Peptide OM-LV20 protects astrocytes against oxidative stress via the ‘PAC1R/JNK/TPH1’ axis

doi: 10.1016/j.jbc.2022.102429

Figure Lengend Snippet: Neuroprotective mechanism of OM-LV20 in astrocytes. Peptide OM-LV20 exerts protective effects on astrocytes via the ‘PAC1R/JNK/TPH1’ axis to resist oxidative stress.

Article Snippet: Primary antibodies included the following: GAPDH (1:3000; Proteintech); p-JNK, JNK, p-p38, and p38 (1:2000; Cell Signaling); TPH1 (1:500; Abcam); and PAC1R (1:500; ABclonal).

Techniques: